Recent Publications

2010

A. Neagu, V. Mironov, I. Kosztin, B. Barz, M. Neagu, R. M. Moreno-Rodriguez, R. R. Markwald, and G. Forgacs
Computational modeling of epithelial-mesenchymal transformations
Biosystems 100 , 22 (2010).
doi: 10.1016/j.biosystems.2009.12.004

G. Forgacs and I. Kosztin
Cellular aggregates under pressure
Physics 3 , 43 (2010).
doi: 10.1103/Physics.3.43

Karoly Jakab, Cyrille Norotte, Francoise Marga, Keith Murphy, Gordana Vunjak-Novakovic and Gabor Forgacs
Tissue engineering by self-assembly and bio-printing of living cells
Biofabrication 2 , 1 (2010).

Fleming, P.A., Gentile, C., Neagu, A., Argraves, W.S., Forgacs, G. and Drake, C.J.
Fusion of uniluminal vascular spheroids: a model for assembly of blood vessels
Dev. Dyn. 239 , 398 (2010).

Visconti RP, Kasyanov V, Gentile C, Zhang J, Markwald RR and Mironov V.
Towards organ printing: engineering an intra-organ branched vascular tree
Expert Opin Biol Ther 10 , 409 (2010).

G. D. Prestwich
Clinical Biomaterials for Scar-Free Healing and Localized Delivery of Cells and Growth Factors"
Adv. Wound Care 1 , 394 (2010).

A. Skardal, J. Zhang and G. D. Prestwich
Bioprinting Vessel-Like Constructs Using Hyaluronan Hydrogels Crosslinked with Tetrahedral Polyethylene Glycol Tetracrylates
Biomaterials 31 , 6173 (2010).

Zhu, J., Zhang, Y.T., Alber, M.S., and Newman, S.A.
Bare bones pattern formation: a core regulatory network in varying geometries reproduces major features of vertebrate limb development and evolution."
PLoS One 5 , e10892 (2010).

Hajdu Z, Mironov V, Mehesz AN, Norris RA, Markwald RR and Visconti RP
Tissue spheroid fusion-based in vitro screening assays for analysis of tissue maturation
J Tissue Eng Regen Med. , (2010).

A. Skardal, J. Zhang, L. McCoard, X. Xu, S. Oottamasathien and G. D. Prestwich
Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting
Tissue Engineerin , (2010).

A. Skardal, J. Zhang, L. McCoard, S. Oottomasathien and G. D. Prestwich
Dynamically Crosslinked Gold Nanoparticle Hyaluronan Hydrogels
Advanced Material , (2010).

A. Skardal, S. Sarker, A. Crabb, C. A. Nickerson and G. D. Prestwich
The Generation of 3D Tissue Models based on Hyaluronan Hydrogel-Coated Microcarriers within a Rotating Wall Vessel Bioreactor
Biomaterial , (2010).

Newman, S.A., "Dynamical patterning modules."
Editor(s): M. Pigliucci, and G.B. Müller
Collection: Evolution: the Extended Synthesis
Cambridge, MA, MIT Presspp. 281-306 , (2010).

Newman, S.A., and Müller, G.B., "Morphological evolution: epigenetic mechanisms"
Collection: Encyclopedia of Life Sciences
Chichester, U.K., John Wiley & Sons , (2010).

G. D. Prestwich and S. Atzet, "I.2.7. Natural Materials"
Editor(s): Ratner, B.D., Hoffman, A.S., Lemmons, J.E., and Schoen, F.J.
Biomaterials Science: An Introduction to Materials in Medicine , (2010).

J. W. Kuo and G. D. Prestwich, "Chapter 73. Hyaluronic Acid"
Editor(s): P. Ducheyne, K. Healy, D. Hutmacher, J. Kirkpatrick
Materials of Biological Origin, Materials Analysis and Implant Uses, Comprehensive Biomaterials, Elsevier , (2010).

2009

C. Norotte, F.S. Marga, L.E. Niklason and G. Forgacs,
Scaffold-Free Vascular Tissue Engineering Using Bioprinting
Biomaterials 30 , 5910 (2009).
doi: 10.1016/j.biomaterials.2009.06.034

Kasyanov VA, Hodde J, Hiles MC, Eisenberg C, Eisenberg L, De Castro LE, Ozolanta I, Murovska M, Draughn RA, Prestwich GD, Markwald RR, Mironov V
Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized natural scaffold with laser-machined micropores
J Mater Sci Mater Med 20 , 329-337 (2009).

Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR
Organ printing: tissue spheroids as building blocks
Biomaterials 30 , 2164-2174 (2009).
doi: 10.1016/j.biomaterials.2008.12.084

Tkatchenko, TV; Moreno-Rodriguez, RA; Conway, SJ; Molkentin, JD; Markwald, RR; Tkatchenko, AV
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease
Physiological Genomics 39 , 160 (2009).

2008

Damon, B. J, Mezentseva, N. V., Kumaratilake, J. S., Forgacs, G., and Newman, S. A.
Limb bud and flank mesoderm have distinct "physical phenotypes" that may contribute to limb budding
Developmental Biology 321 , 319-330 (2008).

Jakab K, Damon B, Marga F, Doaga O, Mironov V, Kosztin I, Markwald R and Forgacs G.
Relating cell and tissue mechanics: Implications and applications
Developmental Dynamics 237 , 2438-49 (2008).

C. Norotte, F. Marga, A. Neagu, I. Kosztin and G. Forgacs,
Experimental evaluation of apparent tissue surface tension based on the exact solution of the Laplace equation (pdf)
Europhysics Letters 81 , 46003 (2008).

K. Jakab, C. Norotte, B. Damon, F. Marga, A. Neagu, C.L. Besch-Williford, A. Kachurin, K.H. Church, H. Park, V. Mironov, R. Markwald, G. Vunjak-Novakovic and G. Forgacs,
Tissue engineering by self-assembly of cells printed into topologically defined structures,
Tissue Engineering 14 , 413-421 (2008).

Alber, M., Glimm, T., Hentschel, H. G., Kazmierczak, B., Zhang, Y. T., Zhu, J., and Newman, S. A.
The morphostatic limit for a model of skeletal pattern formation in the vertebrate limb
Bulletin of Mathematical Biology 70 , 460 (2008).

Mezentseva, N. V., Kumaratilake, J. S., and Newman, S. A.
The brown adipocyte differentiation pathway in birds: an evolutionary road not taken
BMC Biol 6 , 17 (2008).

Newman, S. A., and Bhat, R.
Dynamical patterning modules: physico-genetic determinants of morphological development and evolution
Physical Biology 5 , 015008 (2008).

Newman, S. A., Christley, S., Glimm, T., Hentschel, H. G., Kazmierczak, B., Zhang, Y. T., Zhu, J., and Alber, M.
Multiscale models for vertebrate limb development
Current Topics in Developmental Biology 81 , 311 (2008).

Schnell, S., Maini, P. K., Newman, T. J., and Newman, S. A.
Multiscale models of developmental systems
Current Topics in Developmental Biology (G. Schatten, Ed.) 81 , 552 (2008).

Schnell, S., Maini, P. K., Newman, S. A., and Newman, T. J.
Multiscale modeling of developmental systems. Introduction
Current Topics in Developmental Biology 81 , xvii (2008).

Mironov V, Kasyanov V, Markwald RR, Prestwich GD
Bioreactor-free tissue engineering: directed tissue assembly by centrifugal casting
Expert Opin Biol Ther 8 , 143-152 (2008).

Mironov V, Kasyanov V, Markwald RR
Nanotechnology in vascular tissue engineering: from nanoscaffolding towards rapid vessel biofabrication
Trends Biotechnol 26 , 338-344 (2008).

Mironov V, Kasyanov V, Drake C, Markwald RR
Organ printing: promises and challenges
Regen Med 3 , 93-103 (2008).

Gentile C, Fleming PA, Mironov V, Argraves KM, Argraves WS, Drake CJ
VEGF-mediated fusion in the generation of uniluminal vascular spheroids
Dev Dyn 237 , 2918-2925 (2008).

2007

F. Marga, A. Neagu, I. Kosztin and G. Forgacs,
Developmental biology and tissue engineering, (pdf)
Birth Defects Research Part C: Embryo Today: Reviews 81 , 320-328 (2007).

E. Flenner, F. Marga, A. Neagu, I. Kosztin and G. Forgacs,
Relating biophysical properties across scales,
Curr Top Dev Biol 81 , 461-483 (2007).

V. Mironov, G. Prestwich and G. Forgacs,
Bioprinting living structures,
J. Mat. Chem. 17 , 2054-2060 (2007).

Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR
Organ printing: tissue spheroids as building blocks
Biomaterials 30 , 2164-2174 (2009).

Alber, M., Chen, N., Lushnikov, P. M., and Newman, S. A.
Continuous macroscopic limit of a discrete stochastic model for interaction of living cells
Physical Review Letters 99 , 168102 (2007).

Christley, S., Alber, M. S., and Newman, S. A.
Patterns of mesenchymal condensation in a multiscale, discrete stochastic model
PLoS Computational Biology 3 , (e76)0743 (2007).

Christley, S., Newman, S. A., and Alber, M. S.
Agent-based model for developmental pattern formation with multiscale dynamics and varying cell geometry
Mathematical modeling of biological systems (A.Deutsch, L. Brusch, H. Byrne, G. de Vries, and H.-P. Herzel, Eds.) I , 155 (2007).

Christley, S., Zhu, X. L., Newman, S. A., and Alber, M. S.
Multiscale agent-based simulation for chondrogenic pattern formation in vitro
Cybernetics and Systems 38 , 707 (2007).

Cickovski, T., Aras, K., Alber, M. S., Izaguirre, J. A., Swat, M., Glazier, J. A., Merks, R. M. H., Glimm, T., Hentschel, H. G. E., and Newman, S. A.
From genes to organisms via the cell: a problem solving environment for multicellular development
Computing in Science & Engineering 9 , 50 (2007).

Newman, S. A.
The Turing mechanism in vertebrate limb patterning
Nature Reviews Molecular Cell Biology 8 , 1P (2007).

Newman, S. A., and Bhat, R.
Activator-inhibitor dynamics of vertebrate limb pattern formation
Birth Defects Research Part C - Embryo Today: Reviews 81 , 305 (2007).

Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR
Organ printing: tissue spheroids as building blocks
Biomaterials 30 , 2164-2174 (2009).

2006

X.Z. Shu, S. Ahmad, Y. Liu, G.D. Prestwich,
Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering
Journal of Biomedical Materials Research 79A , 902-912 (2006).
doi:

B. Hegedus, F. Marga, K. Jakab, K. L. Sharpe-Timms, G. Forgacs,
The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors
Biophysical Journal 91 , 2708-2716 (2006).

K. Jakab, B. Damon, A. Neagu, A. Kachurin, G. Forgacs,
Three-dimensional tissue constructs built by bioprinting
Biorheology 43 , 509-513 (2006).

A. Neagu, I. Kosztin, K. Jakab, B. Barz, M. Neagu, R. Jamison, G. Forgacs,
Computational modeling of tissue self-assembly (pdf)
Modern Physics Letters B 20 , 1217-1231 (2006).

S. A. Newman, G. Forgacs, G. B. Muller,
Before programs: The physical origination of multicellular forms (pdf)
International Journal Of Developmental Biology 50 , 289-299 (2006).

Christley, S., Newman, S. A., and Alber, M.
Agent-based simulation for biological development.
In "Eighteenth European meeting on cybernetics and systems research" (R. Trappl, Ed.), Austrian Society for Cybernetic Studies, Vienna, Austria. , 701-706 (2006).

Christley, S., Newman, S. A., and Alber, M.
Modeling of pattern formation in cell cultures.
In "Artificial life X: proceedings of the Tenth International Conference on the Simulation and Synthesis of Living Systems" (L. M. Rocha, L. S. Yaeger, M. A. Bedau, D. Floreano, R. L. Goldstone, and A. Vespignani, Eds.), MIT Press, Cambridge, MA , 49-55 (2006).

Christley, S., Zhu, X., Newman, S. A., and Alber, M.
Towards agent-based simulation in developmental biology.
In "2006 Agent-Directed Simulation Symposium of the Spring Simulation Multiconference (SMC'06)", Huntsville, AL , 149-156 (2006).

Merks, R. M., Brodsky, S. V., Goligorksy, M. S., Newman, S. A., and Glazier, J. A.
Cell elongation is key to in silico replication of in vitro vasculogenesis and subsequent remodeling.
Developmental Biology 289 , 44-54 (2006).

Mironov V, Kasyanov VA, Yost MJ, Visconti R, Twal W, Trusk T, Wen X, Ozolanta I, Kadishs A, Prestwich GD, Terracio L, Markwald RR
Cardiovascular tissue engineering I. Perfusion bioreactors: a review
J Long Term Eff Med Implants 16 , 111-130 (2006).

Mironov V, Reis N, Derby B
Review: bioprinting: a beginning
Tissue Eng 12 , 631-634 (2006).

2005

A. Neagu, K. Jakab, R. Jamison, G. Forgacs,
Role of physical mechanisms in biological self-organization (pdf)
Physical Review Letters 95 , 178104 (2005).

Z. M. Sun, , J. S. Graham, B. Hegedus, F. Marga, Y. Zhang, G. Forgacs, M. Grandbois,
Multiple membrane tethers probed by atomic force microscopy
Biophysical Journal 89 , 4320-4329 (2005).

Mironov V, Kasyanov V, Zheng Shu X, Eisenberg C, Eisenberg L, Gonda S, Trusk T, Markwald RR, Prestwich GD
Fabrication of tubular tissue constructs by centrifugal casting of cells suspended in an in situ crosslinkable hyaluronan-gelatin hydrogel
Biomaterials 26 , 7628-7635 (2005).