Research Team Member
Medical University of South Carolina-Charleston
The Co-PI is a MD, developmental biologist and tissue engineer with extensive expertise in vasculogenesis and angiogenesis (e.g., discovered an angiogenic effect of PDGF, demonstrated vascular endothelial-mesenchymal transformation, pioneered the use of embryoid body for research on vasculogenesis, demonstrated non-sprouting mechanism of angiogenesis during hypoxia). He has designed a novel perfused bioreactor for circumferential and longitudinal strain for mechanical conditioning of tubular tissue engineered constructs. Together with the PI has developed a novel concept: computer-aided self-assembly of living tissues in 3D hydrogels. The Co-PI's primary role in the project will be the maintenance and mechanical conditioning of postprinted structures using his in-house built perfusion bioreactor. He will contribute to the functional and morphological (histology and immuno-histochemistry) characterization of the printed and assembled organ modules.